Tolvaptan Tablets for Hyponatremia are now FDA Approved

The FDA has approved tolvaptan tablets for use in hyponatremia associated with heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone secretion (SIADH).

The drug is a vasopressin-receptor antagonist. Vaprisol (conivaptan) a simliar drug has been used in the IV form in the hospital.

Tolvaptan will be dispensed with a boxed warning that it only be started in hospitals, where sodium levels can be monitored closely. If sodium levels rise too quickly, osmotic demyelination syndrome can result (theoretically... this is scary, but VERY rare).