Does an impairment in kidney function in the elderly lead to an acceleration in cognitive decline?It appears so, says the authors of a study published in last week's journal of Neurology.
A prospective observational cohort study of nearly 900 elderly patients with CKD but without dementia was conducted using members enrolled in the Rush Memory and Aging Project. The groups were broken into two. One with an estimated GFR (using MDRD equation) >60 and the other group eGFR <60 ml/min. A battery of 19 cognitive tests were given at time zero to obtain a baseline, then repeated annually.
Indeed, a more rapid decline in cognitive function was associated with a decreased eGFR. It is uncertain whether the etiology of CKD mattered. It would also be interesting to know some data on the blood pressure control within the groups. The study was relatively small, and could be improved upon... but, it is thought provoking.
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