Saturday, August 21, 2010

Obesity Related CKD and the Benefit of Weight Loss

Obesity has been recognized as an independent risk factor for chronic kidney disease. What is less well established is the possibility of weight loss leading to renoprotection in those who have obesity related glomeuropathy (ORG).  

A study recently published in the Clinical Journal of the American Society of Nephrology looked at this hypothesis. It was a small study of 63 patients and conducted in China. The study went out 24 months and looked at patients separated into 3 groups: (1) significant weight loss (>3% reduction in BMI), (2) stable weight, (3) significant weight gain (>3% increase in BMI).

Conclusion: Weight loss intervention benefited remission of proteinuria in patients with ORG.

Again, this small, relatively short term Chinese study may be a bit flimsy... but, it is nice to see a statistically significant benefit of weight loss.

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