Monday, January 25, 2010

Doctor Disciplined For Removing Wrong Kidney


MINNEAPOLIS — A urologist has been indefinitely barred from inpatient surgery for removing the wrong kidney of one patient and taking a biopsy from another's patient's pancreas instead of a kidney. Dr. Erol Uke has signed the disciplinary ruling from the Minnesota Board of Medical Practice, agreeing that his actions justify the board's discipline.

The ruling said Uke could regain surgical privileges if the board later determines he's competent to do so.
The Star Tribune reported the ruling did not say where the errors happened, just that Uke removed the wrong kidney in March 2008 and performed the erroneous biopsy about four months later.

Uke declined comment when reached at home by The Associated Press.

Increasing Body Mass Index and Kidney Stone Disease


Does obesity lead to an increased risk for the development of kidney stones? Well, yes and no.

An interesting study this month in the Journal of Urology addresses this question. Previous epidemiological works have reported that obesity is a risk factor for kidney stone disease. However, the effect of increasing degrees of obesity on stone formation has yet to be defined. Is the risk linear? The more obese you are, the higher your risk? Is there a cut off?

This study evaluated claims from a 5-year period (2002 to 2006) in a national private insurance database to identify subjects diagnosed with or treated for kidney stones. From a data set of 95,598 patients, subjects were identified by ICD-9 or CPT codes specific to kidney stone disease.

Conclusions
An obese body mass index is associated with an increased risk of kidney stone disease. However, the magnitude of this risk appears to be stable in the morbidly obese population. Once body mass index (BMI) is greater than 30, further increases do not appear to significantly increase the risk of stone disease.

Is Once Daily Renvela Powder Enough?

As dialysis patients know, hyperphosphatemia is a serious concern and a difficult, daily battle. To combat hyperphosphatemia, it takes a careful consideration of dietary intake with every meal or snack.. and the addition of a 'binder'.

The 'binders' are phosphorous binders that work in the GI tract to trap dietary phosphorous and help to rid the body of the phosphorous the kidneys are otherwise unable to eliminate in the urine. In addition to the annoyance of needing to be mindful of everything you eat, the pill burden of these binders is often tremendous. It is not uncommon for a hemodialysis patient to take anywhere between 3-5 pills with each meal in an effort to control serum phosphorous to goal < 5.0-5.5.

Accordingly, anything that can decrease the pill burden will be welcomed. Fosrenol has had some degree of success with a chewable tablet taken with each meal. Renvela has followed with an unconventional delivery method of its own, a powder form. The powder comes in the strength of 2.4 grams per packet. This is equivalent to three Renvela pills (800 mg each).

A randomized study conducted at local Winthrop Hospital by Dr Fishbane et al was recently published in the American Journal of Kidney Diseases. After a 2-week phosphate-binder washout, patients were randomly assigned to once-daily sevelamer carbonate powder or thrice-daily sevelamer hydrochloride tablets.
Conclusions
Once-daily administration of sevelamer carbonate powder was not as effective in decreasing serum phosphorus levels as thrice-daily administration of sevelamer hydrochloride tablets. Nevertheless, once-daily sevelamer carbonate powder decreased serum phosphorus levels significantly, reaching the KDOQI phosphorus target in most patients. Therefore, once-daily dosing of sevelamer carbonate may be a reasonable alternative.

World Kidney Day, March 11, 2010

Nephrologists Using Social Media Article: Nephrology Times

“I think there was the thought and hope on my side of a marketing and networking platform, but I really haven't found that to be the case because medicine is a very local phenomenon, and Twitter is not.”—Simon Prince, MD



Nephrologists Using Social Media Connect with Far-Flung Colleagues, Health Care Consumers

Victorian, Brande

Recommendations for electronic medical record providers, commentary on the latest medical research, and opinions on movies and sports are just a few of the topics being discussed by nephrologists on Twitter.
Although so far only a handful of them have signed up for the social networking and microblogging service, those who have say that Twitter facilitates connections between people who may not otherwise have crossed paths.
“Twitter is very quick and easy and doesn't take a ton of preparation,” said Simon Prince, MD, Founder of North Shore Nephrology PC in Manhasset, NY, who registered for the service about a year ago.
“You get quick feedback and quick interactions, and you meet different people from all over whom you wouldn't necessarily have a chance to interact with otherwise,” said Dr. Prince, who is also creator of the blog Uremic Frost (www.uremicfrost.com).
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On Twitter, account holders are known by their user names, written in this format: @username. Dr. Prince is @simon prince.
While use is not yet widespread among nephrologists, the larger medical community has taken hold of Twitter and other forms of social media, like Facebook and self-published blogs, using them to connect with health care professionals and consumers from all over the world. As of January 10, 540 hospitals were using such forms of new media, according to a hospital social networking list maintained by Edward Bennett, Director of Web Strategy for the University of Maryland Medical System.
“One reason Twitter is so popular is that it excels in creating instant online communities of people with similar interests—medicine, photography, politics, technology—you name it,” wrote Joshua Schwimmer (@JoshuaSchwimmer; www.jschwimmer.net), MD, Assistant Director of Nephrology at Lenox Hill Hospital and Assistant Professor of Medicine at New York University School of Medicine, in an e-mail exchange. “Your experience is customized entirely based on which users you ‘follow.’”
Everyone is going to...
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Twitter users post 140-character-or-less dispatches, called “tweets,” that are seen by other users who've elected to “follow” them. These tweets may be stand-alone comments; a repeated tweet, or “retweet,” of someone else's update; or a response to another user's tweet.
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Creating an Online Identity

Engagement in social media also enables physicians to establish their own online identity, said Joel Topf (@kidney_boy), MD, a staff nephrologist with St. Clair Specialty Physicians PC in Detroit, MI, and creator of the blog Precious Bodily Fluids (www.pbfluids.com), in a phone interview.
“I have a friend from residency who when you put his name in Google the first thing that comes up is a patient review that's pretty damning. This is something that you are at risk of happening to you if you don't take control of your online presence.
“Everyone is going to have an online identity, and if you don't create it, someone else will.”
Kevin Pho (@kevinmd), MD, a leading physician voice in social media and an internal medicine physician with the Nashua Medical Group in Nashua, NH, started his blog, KevinMD.com (www.kevinmd.com), about five years ago because he wanted to give a physician perspective on medical news, he said in a phone interview.
“You see a lot of studies in the newspaper or on television without a lot of context, so a blog is a great way to interact and answer any questions and offer some perspective on the news that you read.
“A lot of my patients would ask me what do I think about a study, and on my blog I'm able to really give up-to-date and dynamic commentary and opinion, giving a lot of stuff that you read in the media some context, and it's really been great to be able to do that.”
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Tweeting is a natural extension of blogging, said Dr. Pho, who has accumulated over 18,000 followers since joining Twitter about a year and a half ago.
“Twitter offers the opportunity to update my readers more quickly than blogging, and I'm able to respond and interact much more closely with readers on Twitter than I am on my blog just because the medium is really almost conversational.”
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Marketing Potential

A number of practices and hospitals are also engaging in social media as a marketing tool, Dr. Pho noted.
“I think people are starting to realize the marketing potential and the fact that Twitter reaches a lot of people, and they want to really be visible in that social space. … I think that's the forward-thinking thing to do.”
Dr. Prince said he initially thought Twitter would be a useful tool for promoting his five-physician practice.
“I think there was the thought and hope on my side of a marketing and networking platform, but I really haven't found that to be the case because medicine is a very local phenomenon, and Twitter is not.
“It's not like I'm meeting new doctors who are going to refer me patients or I'm finding patients from different sources because I'm talking to people in Ohio and California and in Europe. That marketing and networking component is nice, in a sense, but it doesn't translate necessarily into private-practice medicine and to building a practice.”
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Respecting Boundaries

Maintaining patient confidentiality is perhaps the most important aspect physician users of social media must keep in mind, agreed those interviewed for this article.
“I am always checking when I write something to see am I giving up someone's privacy,” Dr. Topf said. “It's something you have to continually ask yourself when you talk about real patients.
“I do talk about real patients, but of course I never give names, and I try to change some of the facts to provide them anonymity and honestly to protect myself because, although it might seem innocent, people are really personal about their health.”
Dr. Pho said he makes it a personal policy not to blog about patients under any circumstances, restricting his commentary to current medical events and news in order to protect himself from such risks.
“Doctors who do talk about patients or cases have to be careful about what they tweet or post on blogs because once it's out there and indexed by search engines … it's very hard to erase, so I think that's something that any medical professional needs to be aware of.”
When asked his thoughts on the use of Twitter to give real-time details of medical procedures like surgery, Dr. Pho said it's a very powerful tool but patient privacy has to be first and foremost.
“As long as it's done with the patient's permission and the patient is aware of what it entails, then I certainly don't see a problem with it.”
Dr. Prince said he has used Twitter for real-time updates of personal events, like the birth of his first child last summer, and to give information on professional activities, like medical procedures and patient consults.
“I think there is a line that should not be crossed with confidentiality, but I think it also generates interesting discussion and input from professionals who are involved in patient care as well,” he said.
While the physicians said they will answer health questions that are asked on their blogs, they are very careful about these interactions.
“I think doctors are held to a higher standard in terms of what they write,” Dr. Pho said. “Patient privacy has to come first and foremost, and because of liability and malpractice, I probably wouldn't give any medical advice.
“From a patient standpoint, I probably wouldn't take any medical advice from social networks either because you can't really confirm that whom you're talking to online or on Twitter or Facebook is really a doctor or medical professional, so I think that works both ways.”
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A Timely Commitment

One downside of social media is that you have to carefully manage your time and attention, Dr. Schwimmer wrote in his e-mail.
“There's too much potentially useful information out there. Learning how to search efficiently, manage the signal-to-noise ratio, and connect productively with others online—these are new skills for the 21st century.”
Dr. Prince agreed, noting that it is hard to keep up with his nearly 1,300 followers on Twitter.
“In order to be a good networker it needs to be a little more give-and-take. You have to respond to tweets, not just tweet on your own, and it's hard sometimes to see what's going on and be responsive to and follow other people's tweets and trains of thoughts. That part is challenging. There is a time commitment to doing it well.”
For Dr. Topf, blogging is a more deliberate online activity than Facebook or Twitter, both of which he tends to during downtime for maybe 20 minutes a day.
He averages about two to three blog posts per week, each of which takes anywhere from 15 minutes to two hours to write, depending on the topic.
“When I have grand rounds, I consider it a pretty good showing if we get 80 people, and I get more than that every day on my blog. In my view, out of any other way that I could get to talk to people about nephrology, this is the widest audience.”
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Mind the Gap

The use of social networking also reveals a generation gap between established physicians who are newer to the medium and younger physicians and medical students who are the more traditional users of new media.
In a survey study of 130 US medical schools that was published in the Journal of the American Medical Association (2009;302: 1309–1315), 60% of the 78 schools that responded to the survey reported incidents of students posting unprofessional content online, including profanity, frankly discriminatory language, depiction of intoxication, and sexually suggestive material.
“I think some of the more established professionals or senior physicians are coming onto this and maybe have a different threshold for discussing things, and the younger generation is so at ease and comfortable using social media that their filter might be skewed and needs to be adjusted appropriately as they become more professional—as students and undergraduates before medical school, and then as they progress on,” Dr. Prince said.
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Medical students have always had inappropriate discussions about personal experiences, Dr. Topf said. The difference now is that the Internet leaves a trail of these discussions for the public to see.
“My sense is you're going to see a change in society where people are going to be less concerned about what comes up online. People have such a long history of online life, so the only way to deal with that is for people to become a little more forgiving of these old transgressions.
“I can't imagine that you're going to want employees, students, and residents to never be able to express a thought or idea, or that a minor transgression online would permanently scar them.
“I think during this transition, people will be harmed by this behavior, but I think in the long run the way society is going to react to this is we're not going to exclude good people.”
Morals and ethics are not particularly different for students and younger physicians than they are for more established physicians, Dr. Topf said.
“We just didn't have this publishing platform. I think that's the long-term issue, but the reality is right now you've got to be careful with it.”
In spite of the various concerns, the most important rule of social networking is to embrace new technology and enjoy yourself, the physicians interviewed agreed.
“Facebook and Twitter seem to be dominating the social media sphere, but we always need to be aware of what may be coming around the corner because what may be popular today may not be so tomorrow,” Dr. Pho said.
“I think it's an exciting place to be and really provides a change of pace from what I do in primary care.”
© 2010 Lippincott Williams & Wilkins, Inc.


Sunday, January 24, 2010

ASN's New Logo



From the ASN website...

ASN: Moving Forward

A major survey conducted in 2008 revealed that ASN members and other stakeholders valued ASN's efforts supporting education, research, and hosting ASN Renal Week. However, many were unaware of ASN's active role addressing concerns in patient care and policy worldwide. As a result, ASN leaders began to evaluate how the Society presents its goals and achievements. In 2009, ASN introduced its tagline, "Leading the fight against kidney disease," and began developing a new logo and visual identity that would embody ASN's ever more active role in the kidney community.

These changes recognize the effort, drive, and results ASN members bring to kidney care and reflect the Society’s evolution in the global kidney community. The new logo is but one of many steps ASN will take between now and its 50th anniversary in 2016 to celebrate the society's commitment to improving lives through advancing research, clinical care, education, and public policy.

What do you think? Is the new logo better or worse than the old one?



Wednesday, January 20, 2010

Hit Movie Avatar May Be Hazardous To Your Health


A Taiwanese man with a history of high blood pressure has died of a stroke that an emergency room doctor says was likely triggered from over-excitement while watching the 3D blockbuster Avatar.

The 42-year-old man, who suffered from hypertension, was rushed to the hospital after he began feeling ill during the screening of the movie earlier this month in the Taiwanese city of Hsinchu, AFP says.

The man identified only as Kuo was unconscious when he got to Nan Men General Hospital where a scan showed that his brain was hemorrhaging, Dr. Peng Chin-Chih, an emergency room doctor, told AFP.

"It's likely that the over-excitement from watching the movie triggered his symptoms," the doctor told AFP.
Kuo died 11 days later from the brain hemorrhage.

Wednesday, January 13, 2010

Bystolic, Shot Down by FDA for Heart Failure Indication


Silver Spring, MD (updated January 13, 2010) - An FDA advisory panel voted unanimously not to recommend approval of nebivolol (Bystolic, Forest Laboratories) for the treatment of chronic heart failure. The FDA had already announced it was leaning away from expanding the drug's indication from hypertension, for which it has been available for several years, to include heart failure, for which there are currently only two approved beta blockers in the US.

The main reason both the panel and the FDA opposed the approval: a weak showing in the only trial submitted in its support, the Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors with Heart Failure (SENIORS).

The drug is already available for heart failure in 71 countries, its advocates said at the hearing.

The 8-0 vote from the Cardiovascular and Renal Drugs Advisory Committee followed a day in which panelists had shown a willingness to overlook certain protocol changes made during the trial that had concerned the FDA.

But there was at least one door left open: most of the panel agreed that there's room for additional nebivolol trials in heart failure, although probably a noninferiority comparison with other beta blockers, not a placebo-controlled trial. "I think most of us agreed in the end that if [the sponsor] wants to pursue this indication," Dr Darren McGuire, an FDA advisory panelist said, "SENIORS could count as one of the two positive trials required."

ARBs Linked to Lower Dementia Risk

Per the MedPage Today

Tuesday, January 12, 2010

Increased Risk of Colonic Perforation During Colonoscopy in Hemodialysis Patients


Colonoscopies are relatively benign procedures. They are done commonly and can be life saving. Furthermore, aside from "the prep" and anxiety associated with the unpleasant nature of this procedure complications are rare. The most dangerous complication is a perforation of the colon. A perforation of the colon is rare but carries a high mortality rate.

An article in Clinical Gastroenterology and Hepatology takes a look at hemodialysis patients who have undergone colonoscopies. It is a retrospective study of more than 15,000 patients in Japan who had colonoscopies between 2001 and 2008. Approximately 1100 hemodilaysis patients were compared to 14,000 controls. There was 5 colon perforations in the 1100 HD patients, whereas there was only 3 perfs in the 14,000 controls. This was a statistically significant difference and the cause is postulated to be from beta-2 microglobulin deposition in the colon wall.

As is the case with all retrospective studies flaws can be found, and the Japanese HD patient doesnt necessarily equate to the HD patient in the USA. Nevertheless, there may be a higher risk of this potentially lethal complication and certainly something to be aware of.

NKF's "Make a Difference"

Thursday, January 7, 2010

Stage IV CKD in New England Journal of Medicine



The New England Journal of Medicine has published an article in the latest issue relevant to everyone in the field of nephrology. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors' clinical recommendations.

Amgen’s, J&J’s Anemia Drugs Face FDA Advisory Review


Jan. 7 (Bloomberg) -- Amgen Inc. and Johnson & Johnson face a review of their top-selling anemia drugs by an advisory panel for the U.S. Food and Drug Administration.

The FDA will ask its advisers to evaluate whether lower doses would avoid increased risks of blood clots and heart attacks in patients with chronic kidney disease. The panel was announced in a New England Journal of Medicine commentary.

Amgen’s Aranesp and Epogen and Johnson & Johnson’s Procrit are known as erythropoiesis-stimulating agents, or ESAs, and are used to boost levels of hemoglobin, an element of red blood cells. Sales of the Amgen anemia drugs fell 15 percent to $5.6 billion in 2008 from their high in 2006 after cardiovascular risks began to emerge in 2007.

“Randomized trials have endeavored to show that using ESAs to raise hemoglobin concentration to higher targets improves clinical outcomes,” Robert Temple, deputy director for clinical science at the FDA’s Center for Drug Evaluation and Research, and his colleagues wrote in the commentary. “Unfortunately and unexpectedly, all results have suggested the opposite.”

The advisory committee meeting “will provide an opportunity to discuss the latest evidence on the benefits and risks of ESAs for patients with chronic kidney disease,” Amgen spokeswoman Emma Hurley said yesterday in an e-mail. The company has already updated prescribing information for its anemia drugs to highlight the risks, she said.



Monday, January 4, 2010

The Top 10 Nephrology Stories of 2009

I hope everyone had a great holiday season. A happy and healthy 2010 to everyone. Before, letting 2009 go... I would be remiss if I didnt put a top ten list up. This one is courtesy of Renal Business Today:

1. Bundling Report Hits the Streets

2. CROWNWeb Delays Full Implementation

3. Healthcare Reform Debates Heat Up

4. The Swine Flu Hits the World

5. Lab Pays Gigantic Sum for Fraud

6. Lufkin Nurse Turns Herself In

7. Dialysis Machine Inventor Dies

8. Dialysis Population/Costs Continue to Rise

9. Aranesp Has Disappointing Results

10. ICD-Roll Out Pushed to 2013