CJASN this month out of Rochester, NY regarding mortality and hyponatremia.
It is well known that severe hyponatremia (defined as Na <120) carries a high mortality rate. But is the mortality a consequence of the hyponatremia itself, or the underlying disease causing the hyponatremia?
This study showed that it was the nature of the underlying illness rather than the severity of the hyponatremia that best explained the associated mortality. Furthermore, it was noted that neurologic symptoms were surprisingly uncommon in those dying from / with hyponatremia.